ntibody Blockade of CCL25/CCR9 Ameliorates Early but not Late hronic Murine Ileitis
نویسندگان
چکیده
ESÚS RIVERA–NIEVES,* JOHNSON HO,* GIORGOS BAMIAS,* NATALIA IVASHKINA, KLAUS LEY, ,¶ ARTIN OPPERMANN, and FABIO COMINELLI* Digestive Health Center of Excellence, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia; Department of Cellular and Molecular mmunology, Georg-August University, Gottingen, Germany; and Robert M. Berne Cardiovascular Research Center, Department of Biomedical Engineering, and Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia
منابع مشابه
CCL25/CCR9 Interactions Regulate the Function of iNKT Cells in Oxazolone-Induced Colitis in Mice
BACKGROUND Natural killer T (NKT) cells share phenotypic and functional properties with both conventional natural killer cells and T cells. These cells might have an important role in the pathogenesis of ulcerative colitis (UC). The interaction of chemokine ligand 25 (CCL25) with chemokine receptor 9 (CCR9) is involved in gut-specific migration of leukocytes and induces regulatory T cells (Treg...
متن کاملCCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation
Airway inflammation is the most common hallmark of allergic asthma. Chemokine receptors involved in leukocyte recruitment are closely related to the pathology in asthma. CCR9 has been described as a homeostatic and inflammatory chemokine receptor, but its role and that of its ligand CCL25 during lung inflammation remain unknown. To investigate the role of CCR9 as a modulator of airway inflammat...
متن کاملAbrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice
INTRODUCTION Biological drugs are effective in patients with rheumatoid arthritis (RA), but increase severe infections. The CC chemokine receptor (CCR) 9 antagonist was effective for Crohn's disease without critical adverse effects including infections in clinical trials. The present study was carried out to explore the pathogenic roles of chemokine (C-C motif) ligand (CCL) 25 and its receptor,...
متن کاملDemonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed intestinal mucosa.
It has recently been suggested that C-C chemokines may play a role in the organ-specific homing of lymphocytes, but there is not enough in vivo evidence in intestinal mucosa. The aim of this study was to examine whether thymus-expressed chemokine (TECK)/CCL25 and its ligand CCR9 are involved in T-lymphocyte interaction with microvessels of murine intestinal mucosa. T lymphocytes from the small ...
متن کاملMice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes.
CC chemokine receptor (CCR) 9, the receptor for the CC-chemokine CCL25/thymus-expressed chemokine (TECK), is mainly expressed by thymocytes and by intraepithelial (IEL) and lamina propria lymphocytes of the small intestine. To study the biologic role of CCR9, a mouse strain was generated in which the CCR9 gene was deleted. In spite of the high level of CCR9 found in double- and single-positive ...
متن کامل